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KMID : 0043320080310050666
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Archives of Pharmacal Research
2008 Volume.31 No. 5 p.666 ~ p.670
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A New Pancreatic Lipase Inhibitor Isolated from the Roots of Actinidia arguta
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Jang Dae-Sik
Lee Ga-Young
Kim Jung-Hyun
Lee Yun-Mi
Kim Jong-Min
Kim Young-Sook
Kim Jin-Sook
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Abstract
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A new coumaroyl triterpene, 3-O-trans-p-coumaroyl actinidic acid (1), as well as five known triterpenes, ursolic acid (2), 23-hydroxyursolic acid (3), corosolic acid (4), asiatic acid (5) and betulinic acid (6) were isolated from an EtOAc-soluble extract of the roots of Actinidia arguta. The structure of compound 1 was elucidated from interpretation of the spectroscopic data, particularly by extensive 1D and 2D NMR studies. All the isolates (1-6) were evaluated in vitro for their inhibitory activities on pancreatic lipase (PL). Of the isolates, the new compound 1 possessed the highest inhibitory activity on PL, with an of , followed by ursolic acid (2, ). The other four triterpenes (3-6) also showed significant PL inhibitory activity, with values ranging from 20.42 to ).
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KEYWORD
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Actinidia arguta, Actinidiaceae, 3-O-trans-p-Coumaroyl actinidic acid, Triterpene, Pancreatic lipase, Obesity
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